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Term Definition
Alzheimer Europe, 2009
Alzheimer Europe (2009). Who is affected by Alzheimer's disease?
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Alzheimer Europe, 2010
Alzheimer Europe (2010). Alzheimer's disease.
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Alzheimer Europe, 2010
Alzheimer Europe (2010). The impact of Alzheimer's disease in Europe.
Hits: 145
Alzheimer Europe, 2014
Hits: 137
Arab, 2011
Arab L et al (2011). Gender Differences in Tea, Coffee, and Cognitive Decline in the Elderly: The Cardiovascular Health Study. J Alzheimers Dis. Aug 12. [Epub ahead of print]
Hits: 141
Arab, 2013
Arab L. et al. (2013) Epidemiologic Evidence of a Relationship between Tea, Coffee, or Caffeine Consumption and Cognitive Decline. Adv Nutr, vol. 4:115-122.
Hits: 99
Arendash, 2006
Arendash GW et al (2006). Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain β-amyloid production. Neuroscience;142:941-52.
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Arendash, 2009
Arendash GW et al (2009). Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice. J Alzheimers Dis;17:661-80.
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Ascherio, 2001
Ascherio A et al (2001). Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Ann Neurol;50:56-63.
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Ascherio, 2003
Ascherio A et al (2003). Caffeine, postmenopausal estrogen, and risk of Parkinson's disease. Neurology;60:790-5.
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Barranco Quintana, 2007
Barranco Quintana JL et al (2007). Alzheimer's disease and coffee: a quantitative review. Neurol Res;29:91-5.
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Beydoun, 2014
Beydoun M.A. et al. (2014) Caffeine and Alcohol Intakes and Overall Nutrient Adequacy Are Associated with Longitudinal Cognitive Performance among U.S. Adults. J Nutr, published online ahead of print, Available at:
Hits: 130
Broe, 1990
Broe GA et al (1990). A case-control study of Alzheimer's disease in Australia. Neurology;40:1698-707.
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Cao, 2009
Cao C et al (2009). Caffeine suppresses amyloid-β levels in plasma and brain of Alzheimer's disease transgenic mice. J Alzheimers Dis;17:681-97.
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Cao, 2011
Cao C et al (2011). Caffeine synergizes with another coffee component to increase plasma GCSF: linkage to cognitive benefits in Alzheimer's mice. J Alzheimers Dis; 25(2):323-35.
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Cao, 2012
Cao C. et al. (2012) High blood caffeine levels in MCI linked to lack of progression to dementia. J Alzheimers Dis, 30:559-572.
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Chen, 2001
Chen JF et al (2001). Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci;21:RC143.
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Cho, 2005
Cho JY et al (2005). Inhibitory effects of long-term administration of ferulic acid on astrocyte activation induced by intracerebroventricular injection of beta-amyloid peptide (1-42) in mice. Prog Neuropsychopharmacol Biol Psychiatry;29:901-7.
Hits: 141
Corley, 2010
Corley J et al (2010). Caffeine consumption and cognitive function at age 70: The Lothian birth cohort 1936 study. Psychosom Med;72:206-14.
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Costa, 2010
Costa J et al (2010). Caffeine exposure and the risk of Parkinson's disease: a systematic review and meta-analysis of observational studies. J Alzheimers Dis;20 Suppl 1:S221-38.
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Cropley, 2011
Cropley V et al (2011). Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study. Psychopharmacology (Berl); 219(3):737-49.
Hits: 125
EPDA, 2011a
European Parkinson's Disease Association (2011). EPDA Annual report 2010-2011.
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EPDA, 2011b
European Parkinson's Disease Association (2011). Life with Parkinson's.
Hits: 124
Eskelinen, 2009
Eskelinen MH et al (2009). Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis;16:85-91.
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Fall, 1999
Fall PA et al (1999). Nutritional and occupational factors influencing the risk of Parkinson's disease: a case-control study in southeastern Sweden. Mov Disord; 14:28-37.
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Fenu en Morelli, 1998

Fenu S & Morelli M (1998). Motor stimulant effects of caffeine in 6-hydroxydopamine-lesioned rats are dependent on previous stimulation of dopamine receptors: a different role of D1 and D2 receptors. Eur J Neurosci;10:1878-84.

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Gelber, 2011
Gelber RP et al (2011). Coffee intake in midlife and risk of dementia and its neuropathologic correlates. J Alzheimers Dis;23:607-15.
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Hameleers, 2000
Hameleers PA et al (2000). Habitual caffeine consumption and its relation to memory, attention, planning capacity and psychomotor performance across multiple age groups. Hum Psychopharmacol;15:573-581.
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Han, 2009
Han ME et al (2009). Regulation of cerebrospinal fluid production by caffeine consumption. BMC Neurosci;10:110.
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Hellenbrand, 1996
Hellenbrand W et al (1996). Diet and Parkinson's disease. I. A possible role for the past intake of specific foods. Results from a self-administered food-frequency questionnaire in a case-control study. Neurology;47:636-43.
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Hernan, 2002
Hernan MA et al (2002). A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease. Ann Neurol;52:276-84.
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Hogervorst, 1998
Hogervorst E et al (1998). Caffeine improves memory performance during distraction in middle-aged, but not in young or old subjects. Hum Psychopharmacol;13:277-284.
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Jarvis, 1993
Jarvis MJ (1993). Does caffeine intake enhance absolute levels of cognitive performance? Psychopharmacology;110:45-52.
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Jimenez-Jimenez, 1992
Jimenez-Jimenez FJ et al (1992). Premorbid smoking, alcohol consumption, and coffee drinking habits in Parkinson's disease: a case-control study. Mov Disord; 7:339-44.
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Johnson-Kozlow, 2002
Johnson-Kozlow M et al (2002). Coffee consumption and cognitive function among older adults. Am J Epidemiol;156:842-850.
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Kim, 2004
Kim HS et al (2004). Inhibitory effects of long-term administration of ferulic acid on microglial activation induced by intracerebroventricular injection of beta-amyloid peptide (1-42) in mice. Biol Pharm Bull;27:120-1.
Hits: 134
Kuwana, 1999
Kuwana Y et al (1999). Antiparkinsonian activity of adenosine A2A antagonists in experimental models. Adv Neurol, 80:121-3.
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Laitala, 2009
Laitala VS et al (2009). Coffee drinking in middle age is not associated with cognitive performance in old age. Am J Clin Nutr;90:640-6.
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Lammi, 1989
Lammi UK et al (1989). Mental disability among elderly men in Finland: prevalence, predictors and correlates. Acta Psychiatr Scand;80:459-68.
Hits: 110
Larsson en Orsini, 2011
Larsson SC & Orsini N (2011). Coffee consumption and risk of stroke: A dose-response meta-analysis of prospective studies. Am J Epidemiol; Sep 13. [Epub ahead of print]
Hits: 197
Larsson, 2008
Larsson SC et al (2008). Coffee and tea consumption and risk of stroke subtypes in male smokers. Stroke;39:1681-7.
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Larsson, 2011
Larsson SC et al (2011). Coffee consumption and risk of stroke in women. Stroke;42:908-12.
Hits: 133
Lida, 1999
Iida M et al (1999). Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res; 838:51-9.
Hits: 147
Lindsay, 2002
Lindsay J et al (2002). Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol;156:445-53.
Hits: 135
Liu, 2012
Liu R. et al. (2012) Caffeine intake, smoking, and risk of Parkinson disease in men and women. Am J Epidemiol, 175(11):1200-7.
Hits: 138
Lopez-Garcia, 2009
Lopez-Garcia E et al (2009). Coffee consumption and risk of stroke in women. Circulation;119:1116-23.
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Lorist, 1995
Lorist MM et al (1995). Aging, caffeine, and information processing: an event-related potential analysis. Electroencephalogr Clin Neurophysiol;96:453-467.
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Maia en de Mendonça, 2002

Maia L & de Mendonça A (2002). Does caffeine intake protect from Alzheimer's disease? Eur J Neurol;9:377-82.

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Morelli, 2009
Morelli M et al (2009). Adenosine A2A receptors and Parkinson's disease. Handb Exp Pharmacol;193:589-615.
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Nefzger, 1968
Nefzger MD et al (1968). A retrospective study of smoking in Parkinson's disease. Am J Epidemiol; 88:149-158.Nefzger, M. D. (Nat. Research Council, Washington, D. C. 20418), F. A. Quad-fasel and V. C Karl. A retrospective study of smoking in Parkinson's disease.Amer. J. Epid., 1968, 88: 149–158.
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Palacios, 2010
Palacios N. et al. (2010) Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson's disease in men and women. Parkinsonism Relat Disord, 16:370-5.
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Palacios, 2012
Palacios N. et al. (2012). Caffeine and Risk of Parkinson's Disease in a Large Cohort of Men and Women. Movement Disorders, published online ahead of print.Palacios N. et al. (2012). Caffeine and Risk of Parkinson's Disease in a Large Cohort of Men and Women. Movement Disorders, published online ahead of print.
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Piriyawat, 2003
Piriyawat P et al (2003). Pilot dose-escalation study of caffeine plus ethanol (caffeinol) in acute ischemic stroke. Stroke;34:1242-5.
Hits: 133
Postuma, 2012
Postuma R.B. et al. (2012), Caffeine for treatment of Parkinson disease: A randomized controlled trial. Neurology, 79(7): 651–658.
Hits: 143
Qi, 2014
Qi H. et al. (2014) Dose–response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease. Geriatr Gerontol Int, (2):430-9.
Hits: 136
Rees, 1999
Rees K et al (1999). The influences of age and caffeine on psychomotor and cognitive function. Psychopharmacology (Berl);145:181-188.
Hits: 137
Ritchie, 2007
Ritchie K et al (2007). The neuroprotective effects of caffeine: a prospective population study (the Three City Study). Neurology;69:536-545.
Hits: 108
Ryan, 2002
Ryan L et al (2002). Caffeine reduces time-of-day effects on memory performance in older adults.Psychol Sci;13:68-71.
Hits: 133
Santos, 2010a

Santos C et al (2010). Caffeine intake and dementia: systematic review and meta-analysis. J Alzheimers Dis;20 Suppl 1:S187-204.

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Santos, 2010b
Santos C et al (2010). Caffeine intake is associated with a lower risk of cognitive decline: a cohort study from Portugal. J Alzheimers Dis;20 Suppl 1:S175-85.
Hits: 135
Singh-Manoux, 2011
Singh-Manoux A et al (2011). Timing of onset of cognitive decline: results from Whitehall II prospective cohort study. BMJ; 343:d7622 doi: 10.1136/bmj.d762
Hits: 141
Smith, 1994
Smith AP (1994). Caffeine, performance, mood and status of reduced alertness. Pharmacopsychoecologia;7:75-86.
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Smith, 2005b
Smith AP (2005). Caffeine. In Nutritional Neuroscience, Lieberman H, Kanarek R, Prasad C, eds. Taylor & Francis, Boca Raton, FL;pp. 335-359.
Hits: 130
Swift en Tiplady, 1988
Swift CG & Tiplady B (1988). The effects of age on the response to caffeine. Psychopharmacology (Berl);94:29-31.
Hits: 139
Tohda, 2005a
Tohda C et al (2005). Search for natural products related to regeneration of the neuronal network. Neurosignals;14:34-45.
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Tohda, 2005b
Tohda C et al (2005). Search for natural products related to regeneration of the neuronal network. Neurosignals;14:34-45.
Hits: 133
Tyas, 2001
Tyas SL et al (2001). Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada. Int J Epidemiol;30:590-7.
Hits: 107
van der Mark, 2014
van der Mark M. et al. 2014, A Case-Control Study of the Protective Effect of Alcohol, Coffee, and Cigarette Consumption on Parkinson Disease Risk: Time-Since-Cessation Modifies the Effect of Tobacco Smoking, PLoS One, published online ahead of print, doi: 10.1371/journal.pone.0095297
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Van Gelder, 2007
Van Gelder BM et al (2007). Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study. Eur J Clin Nutr;61:226-32.
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Van Hooren, 2005
Van Hooren SA et al (2005). Influence of cognitive functioning on functional status in an older population: 3- and 6-year follow-up of the Maastricht Aging Study. Int J Geriatr Psychiatry; 20:883-888.
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Vercambre, 2013
Vercambre M.-N. et al. (2013) Caffeine and Cognitive Decline in Elderly Women at High Vascular Risk. J Alzheimers Dis, 35(2):413-21.
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Webster Ross, 2000
Webster Ross G et al (2000). Association of coffee and caffeine intake with the risk of Parkinson disease. JAMA; 283:2674-2679.
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World Heart Foundation
World Heart Federation, ‘Cardiovascular Health: Stroke’ Available at:
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Wostyn, 2011
Wostyn P et al (2011). Increased cerebrospinal fluid production as a possible mechanism underlying caffeine's protective effect against Alzheimer's disease. Int J Alzheimers Dis;2011:617420.
Hits: 140
Wu, 2011
Wu MS et al (2011). Socio-demographic and health-related factors associated with cognitive impairment in the elderly in Taiwan. BMC Public Health;11:22.
Hits: 112